Effects of Nutrient Deprivation
Einstein scientists have discovered that nutrient deprivation links two key cellular processes, autophagy and ciliogenesis. (Autophagy involves degrading and recycling worn-out proteins and other molecules; ciliogenesis is the formation of cilia, the antenna-like structures that protrude from the cell surface.) A paper in an October online issue of Nature from the laboratories of Ana Maria Cuervo, M.D., Ph.D., and Peter Satir, Ph.D., demonstrated a reciprocal relationship between autophagy and ciliogenesis.
After nutrients were withheld, cell lines with compromised ciliogenesis experienced reduced rates of protein degradation due to defective autophagy. The researchers found that a particular signaling pathway mediates the relationship between the two processes. These findings suggest that the pathology underlying certain ciliopathies—diseases caused by defects in the function or structure of cilia—may result from impaired activation
Dr. Cuervo is professor of developmental and molecular biology, of anatomy and structural biology and of medicine (gastroenterology & liver diseases) and is the Robert and Renée Belfer Chair for the Study of Neurodegenerative Diseases. Dr. Satir is distinguished university professor of anatomy and structural biology. The paper’s first author was Olatz Pampliega, Ph.D., a postdoctoral fellow in the Cuervo lab.